Anti-SOX17抗体(ab83258)

概述

• 产品名称
  Anti-SOX17抗体
  参阅全部 SOX17 一抗
• 描述
  兔多克隆抗体to SOX17
• 经测试应用
  适用于: WB, ELISA, IHC-Pmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Guinea pig, Dog
• 免疫原

  Synthetic peptide corresponding to Human SOX17 aa 360-409 (internal sequence).
  Sequence:

  RTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGAISSVVSDASSAVYYC

  Run BLAST with Run BLAST with
• 阳性对照
  • HeLa cell lysate.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 纯化说明
  Purified by peptide affinity chromatography method.
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HMG Box

  • Stem Cells
  • Embryonic Stem Cells
  • Intracellular

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Developmental Biology
  • Embryogenesis
  • Embryonic stem cells
  • Surface molecules

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

应用

靶标

• 功能
  Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
• 组织特异性
  Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
• 疾病相关
  Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:613674]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
• 序列相似性
  Contains 1 HMG box DNA-binding domain.
  Contains 1 Sox C-terminal domain.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession Q9H6I2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 64321 Human
  • Entrez Gene: 20671 Mouse
  • Entrez Gene: 312936 Rat
  • Omim: 610928 Human
  • SwissProt: Q9H6I2 Human
  • SwissProt: Q61473 Mouse
  • Unigene: 98367 Human
  • Unigene: 279103 Mouse
• 别名
  • FLJ22252 antibody
  • SOX17 antibody
  • SOX17_HUMAN antibody

  • SRY (sex determining region Y) box 17 antibody
  • SRY box 17 antibody
  • SRY related HMG box transcription factor SOX17 antibody
  • Transcription factor SOX-17 antibody
  • Transcription factor SOX17 antibody
  • VUR3 antibody

  see all

实验方案

• Western blot protocols
• Immunohistochemistry protocols