Anti-SOS1抗体[AF3F11] (ab82429)

概述

  • 产品名称Anti-SOS1抗体[AF3F11]
    参阅全部 SOS1 一抗
  • 描述
    小鼠单克隆抗体[AF3F11] to SOS1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant Human SOS1 with His tag, purified from E.coli.

  • 阳性对照
    • HepG2 cell lysate, HeLa cell lysate, MOLT4 cell lysate, NIH3T3 cell lysate and PC12 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab82429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 152 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Promotes the exchange of Ras-bound GDP by GTP.
  • 组织特异性Expressed in gingival tissues.
  • 疾病相关Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common.
    Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common.
  • 序列相似性Contains 1 DH (DBL-homology) domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 PH domain.
    Contains 1 Ras-GEF domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • alternate SOS1 antibody
    • GF1 antibody
    • GGF1 antibody
    • GINGF antibody
    • gingival fibromatosis antibody
    • gingival fibromatosis hereditary 1 antibody
    • Guanine nucleotide exchange factor antibody
    • HGF antibody
    • NS4 antibody
    • Son of sevenless homolog 1 (Drosophila) antibody
    • Son of sevenless homolog 1 antibody
    • SOS Ras/Rac guanine nucleotide exchange factor 1 antibody
    • SOS-1 antibody
    • Sos1 antibody
    • SOS1_HUMAN antibody
    see all

Anti-SOS1 antibody [AF3F11] 图像

  • All lanes : Anti-SOS1 antibody [AF3F11] (ab82429) at 1/1000 dilution

    Lane 1 : HeLa cell lysates
    Lane 2 : MOLT4 cell lysates
    Lane 3 : HepG2 cell lysates
    Lane 4 : NIH3T3 cell lysates
    Lane 5 : PC12 cell lysates


    Predicted band size : 152 kDa
    Observed band size : 152 kDa

Anti-SOS1 antibody [AF3F11] (ab82429)参考文献

ab82429 has not yet been referenced specifically in any publications.

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