概述

  • 产品名称Anti-SorLA抗体
    参阅全部 SorLA 一抗
  • 描述
    山羊多克隆抗体to SorLA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Cow, Dog, Human
  • 免疫原

    Synthetic peptide:

    TGFSDDVPMVIA

    , corresponding to C terminal amino acids 2203-2214 of Human SORL1.

  • 阳性对照
    • Mouse brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab22814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 246 kDa.
    Peptide ELISA: antibody detection limit dilution 1:4,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
    • 组织特异性Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
    • 序列相似性Belongs to the SORL1 family.
      Contains 5 BNR repeats.
      Contains 1 EGF-like domain.
      Contains 6 fibronectin type-III domains.
      Contains 11 LDL-receptor class A domains.
      Contains 5 LDL-receptor class B repeats.
    • 翻译后修饰The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C11orf32 antibody
      • FLJ21930 antibody
      • FLJ39258 antibody
      • gp250 antibody
      • LDLR relative with 11 ligand binding repeats antibody
      • LDLR relative with 11 ligand-binding repeats antibody
      • Low density lipoprotein receptor relative with 11 ligand binding repeats antibody
      • Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody
      • LR 11 antibody
      • LR11 antibody
      • LRP 9 antibody
      • LRP9 antibody
      • Mosaic protein LR11 antibody
      • SORL 1 antibody
      • SORL_HUMAN antibody
      • SORL1 antibody
      • SorLA 1 antibody
      • SorLA antibody
      • SorLA-1 antibody
      • Sortilin related receptor antibody
      • Sortilin related receptor L(DLR class) A repeats containing antibody
      • Sortilin-related receptor antibody
      • Sorting protein related receptor containing LDLR class A repeats antibody
      • Sorting protein-related receptor containing LDLR class A repeats antibody
      see all

    Anti-SorLA antibody 图像

    Anti-SorLA antibody (ab22814)参考文献

    ab22814 has not yet been referenced specifically in any publications.

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