Anti-Solute carrier family 22 member 5抗体(ab125416)

概述

  • 产品名称Anti-Solute carrier family 22 member 5抗体
    参阅全部 Solute carrier family 22 member 5 一抗
  • 描述
    兔多克隆抗体to Solute carrier family 22 member 5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 305-354 (GIVVPSTIFD PSELQDLSSK KQQSHNILDL LRTWNIRMVT IMSIMLWMTI) of Human Solute carrier family 22 member 5 (NP_003051).

  • 阳性对照
    • OVCAR 3 lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 63 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
  • 组织特异性Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
  • 疾病相关Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP) [MIM:212140]. CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CDSP antibody
    • High-affinity sodium-dependent carnitine cotransporter antibody
    • OCTN2 antibody
    • OCTN2VT antibody
    • Organic cation/carnitine transporter 2 antibody
    • S22A5_HUMAN antibody
    • Slc22a5 antibody
    • Solute carrier family 22 (organic cation/carnitine transporter) member 5 antibody
    • Solute carrier family 22 member 5 antibody
    see all

Anti-Solute carrier family 22 member 5 antibody 图像

  • Anti-Solute carrier family 22 member 5 antibody (ab125416) at 1 µg/ml + OVCAR 3 lysate at 10 µg

    Predicted band size : 63 kDa


  • Predicted band size : 63 kDa

Anti-Solute carrier family 22 member 5 antibody (ab125416)参考文献

ab125416 has not yet been referenced specifically in any publications.

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