Soluble TNF Receptor I肽(2-13) (ab45654)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列AAGQNGHEEWVG-C
    • 氨基酸2 to 13

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-soluble TNF Receptor I antibody (ab28749)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • CD120a
    • TBP1
    • TNFR1
    • TNFR55
    • TNFRSF1A
    • Tumor necrosis factor receptor 1
    see all
  • 相关性TNF RI (CD120a) is a 55 kDa transmembrane glycoprotein that is expressed by virtually all nucleated mammalian cells. Among the numerous cells known to express TNF RI are hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34+ hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF RI. Soluble TNF alpha binds with a Kda in the range of 20-60 pM, while TNF beta binds with a Kda equal to 650 pM. TNF RI relative to TNF RII seems to be the more physiologically relevant receptor, whereas TNF R2 appears to play a direct role in only a limited number of TNF responses. Soluble TNF RI, which blocks TNF alpha activity, has been identified in both urine and blood (1-3 ng/mL). Serum levels of sTNF receptors increase dramatically in certain pathological situations.
  • 细胞定位Cytoplasmic

Soluble TNF Receptor I peptide (2-13) (ab45654)参考文献

ab45654 has not yet been referenced specifically in any publications.

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