Anti-soluble IL2 Receptor gamma抗体[38024.11] (ab50258)

概述

  • 产品名称Anti-soluble IL2 Receptor gamma抗体[38024.11]
  • 描述
    小鼠单克隆抗体[38024.11] to soluble IL2 Receptor gamma
  • 特异性By ELISA, the antibody does not cross react with recombinant human IL2 R alpha, IL2 R beta, IL1 RI, IL1 RII, IL4 R , IL6 R, IL7 R and IL10 R.
  • 经测试应用适用于: WB, Neutralising, Indirect ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human IL2 soluble receptor gamma.

  • 常规说明


    Monoclonal anti-Human IL2 sRg may be used to block the biological activity mediated by IL2 and for neutralization of the biological activity mediated by IL2 Rg and the detection of IL2 Rg.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明The antibody was purified from ascites fluid.
  • Primary antibody说明Monoclonal anti-Human IL2 sRg may be used to block the biological activity mediated by IL2 and for neutralization of the biological activity mediated by IL2 Rg and the detection of IL2 Rg.
  • 克隆单克隆
  • 克隆编号38024.11
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab50258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa.

This working dilution was determined using recombinant human IL2 Rg at 100 ng/lane under non-reducing conditions.

Neutralising Use a concentration of 2 - 6 µg/ml.

This concentration was found to block 50% of the bioactivity due to 10 ng/ml recombinant human IL2 in a 3H-thymidine incorporation assay using 105 cells/ml MO7e cells.

Indirect ELISA Use a concentration of 0.5 - 1 µg/ml.

I-ELISA: Use at a concentration of 0.5 - 1 µg/ml (to a limit of 3 ng/well).

靶标

  • 相关性A common subunit for the receptors for a variety of interleukins, the gamma chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors. Defects in IL2RG are the cause of X-linked severe combined immunodeficiency. The biological effects of IL2R signals are much more complex than simply mediating T-cell growth. Depending on conditions, IL2R signals may also promote cell survival, effector function, and apoptosis. These sometimes contradictory effects underscore the fact that a diversity of intracellular signalling pathways are potentially activated by IL2R. There are at least 3 components of the IL2 receptor; IL2R alpha, IL2R beta, and IL2R gamma chains.
  • 细胞定位Membrane; single-pass type I membrane protein
  • 数据库链接
  • 别名
    • CD132 antibody
    • Cytokine receptor common gamma chain antibody
    • Gamma-C antibody
    • gammaC antibody
    • IL-2 receptor subunit gamma antibody
    • IL-2RG antibody
    • IL2R gamma chain antibody
    • IL2RG antibody
    • IMD4 antibody
    • Interleukin-2 receptor subunit gamma antibody
    • L-2R subunit gamma antibody
    • p64 antibody
    see all

Anti-soluble IL2 Receptor gamma antibody [38024.11] (ab50258)参考文献

ab50258 has not yet been referenced specifically in any publications.

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