功能Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
序列相似性Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
翻译后修饰Phosphorylated by PKA, which inhibits activity.
细胞定位Membrane. In intestinal epithelial cells, localizes to the ileal brush border.