Anti-SOD2/MnSOD抗体(ab118340)

概述

  • 产品名称Anti-SOD2/MnSOD抗体
    参阅全部 SOD2/MnSOD 一抗
  • 描述
    山羊多克隆抗体to SOD2/MnSOD
  • 特异性ab118340 is expected to recognize both reported isoforms (NP_000627.2; NP_001019637.1). The immunizing peptide represents the acetylation site including K122 according to isoform A.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Cow, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Human SOD2/MnSOD aa 119-130 (internal sequence) (Cysteine residue).
    Sequence:

    EAIKRDFGSFDK


    Database link: P04179

  • 阳性对照
    • Mouse and Rat spinal cord and Human Brain (cerebellum) lysates.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab118340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

Antibody detection limit dilution 1:64,000.

WB Use a concentration of 0.01 - 0.1 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 25 kDa).

靶标

  • 功能Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • 疾病相关Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • 序列相似性Belongs to the iron/manganese superoxide dismutase family.
  • 翻译后修饰Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Indophenoloxidase B antibody
    • IPO B antibody
    • IPOB antibody
    • Manganese containing superoxide dismutase antibody
    • Manganese SOD antibody
    • Manganese superoxide dismutase antibody
    • Mangano superoxide dismutase antibody
    • Mn SOD antibody
    • Mn superoxide dismutase antibody
    • MNSOD antibody
    • MVCD6 antibody
    • SOD 2 antibody
    • SOD2 antibody
    • SODM_HUMAN antibody
    • Superoxide dismutase [Mn] mitochondrial antibody
    • Superoxide dismutase [Mn], mitochondrial antibody
    • Superoxide dismutase 2 mitochondrial antibody
    see all

Anti-SOD2/MnSOD antibody 图像

  • All lanes : Anti-SOD2/MnSOD antibody (ab118340)

    Lane 1 : Human Cerebellum lysate
    Lane 2 : Mouse Brain lysate
    Lane 3 : Rat Brain lysate
    Lane 4 : Pig Brain lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 25 kDa
  • All lanes : Anti-SOD2/MnSOD antibody (ab118340)

    Lane 1 : HeLa cell lysate
    Lane 2 : HepG2
    Lane 3 : HEK293
    Lane 4 : NIH3T3

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 25 kDa
  • Anti-SOD2/MnSOD antibody (ab118340) at 0.1 µg/ml (incubation time: 1 hour) + Mouse Spinal Cord lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 25 kDa

Anti-SOD2/MnSOD antibody (ab118340)参考文献

ab118340 has not yet been referenced specifically in any publications.

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