This fast track antibody is not yet fully characterized. It is subject to these terms and conditions


  • 产品名称Anti-SOCS7抗体
    参阅全部 SOCS7 一抗
  • 描述
    兔多克隆抗体to SOCS7

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant SOCS7 protein fragment (Human) expressed in E. coli


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明This antibody is affinity purified.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


  • 应用说明WB: 1/1000. This antibody was tested against the recombinant protein fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • 组织特异性Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Contains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • 结构域The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
    • 细胞定位Cytoplasm. Cell membrane. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Ash and phospholipase C gamma-binding protein antibody
      • NAP 4 antibody
      • NAP 4 Fragment antibody
      • NAP-4 antibody
      • NAP4 antibody
      • Nck antibody
      • Nck Ash and phospholipase C binding protein antibody
      • Nck Ash and phospholipase C gamma binding protein antibody
      • Nck associated protein 4 antibody
      • Nck-associated protein 4 antibody
      • NCKAP4 antibody
      • SH2 domain containing SOCS box protein antibody
      • SOCS 7 antibody
      • SOCS-7 antibody
      • SOCS4 antibody
      • SOCS6 antibody
      • Socs7 antibody
      • SOCS7_HUMAN antibody
      • Suppressor of cytokine signaling 7 antibody
      see all

    Anti-SOCS7 antibody (ab13951)参考文献

    This product has been referenced in:
    • Pereira CP  et al. Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. PLoS One 5:e15352 (2010). WB ; Human . Read more (PubMed: 20976180) »

    See 1 Publication for this product

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