概述

  • 产品名称Anti-SOCS1抗体
    参阅全部 SOCS1 一抗
  • 描述
    兔多克隆抗体to SOCS1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide, corresponding to a 17 amino acid sequence near the N terminal of human SOCS1.

  • 阳性对照
    • Human spleen cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab37167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 24 kDa).

靶标

  • 功能SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
  • 组织特异性Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • 结构域The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CISH 1 antibody
    • CISH1 antibody
    • Cytokine inducible SH2 protein 1 antibody
    • JAB antibody
    • JAK binding protein antibody
    • JAK-binding protein antibody
    • Janus kinase binding protein antibody
    • SOCS 1 antibody
    • SOCS-1 antibody
    • Socs1 antibody
    • SOCS1_HUMAN antibody
    • SSI 1 antibody
    • SSI-1 antibody
    • SSI1 antibody
    • STAT induced STAT inhibitor 1 antibody
    • STAT-induced STAT inhibitor 1 antibody
    • Suppressor of cytokine signaling 1 antibody
    • Supressor of cytokine signalling 1 antibody
    • TEC interacting protein 3 antibody
    • Tec-interacting protein 3 antibody
    • TIP 3 antibody
    • TIP-3 antibody
    • TIP3 antibody
    see all

Anti-SOCS1 antibody 图像

  • Lane 1 : Anti-SOCS1 antibody (ab37167) at 1 µg/ml
    Lane 2 : Anti-SOCS1 antibody (ab37167) at 2 µg/ml
    Lane 3 : Anti-SOCS1 antibody (ab37167) at 4 µg/ml

    Lane 1 : Human spleen cell lysate
    Lane 2 : Human spleen cell lysate
    Lane 3 : Human spleen cell lysate

    Lysates/proteins at 15 µg per lane.

    Secondary
    goat anti-rabbit HRP at 1/10000 dilution

    Predicted band size : 24 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)

Anti-SOCS1 antibody (ab37167)参考文献

This product has been referenced in:
  • Raad H  et al. Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2. Free Radic Biol Med : (2012). Read more (PubMed: 23010498) »
  • Platten M  et al. Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A : (2009). WB ; Mouse . Read more (PubMed: 19706421) »

See all 3 Publications for this product

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