概述

  • 产品名称Anti-SNX17抗体
    参阅全部 SNX17 一抗
  • 描述
    小鼠多克隆抗体to SNX17
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-470 of Human SNX17

  • 阳性对照
    • SNX17 transfected 293T cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

靶标

  • 功能Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
  • 序列相似性Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
    Contains 1 Ras-associating domain.
  • 结构域The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.
    The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
  • 细胞定位Cytoplasm. Early endosome. Cytoplasmic vesicle membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Similar to a putative C elegans gene encoded in cosmid F17H10 antibody
    • Snx17 antibody
    • SNX17_HUMAN antibody
    • Sorting nexin 17 antibody
    • Sorting nexin-17 antibody
    see all

Anti-SNX17 antibody 图像

  • All lanes : Anti-SNX17 antibody (ab67599) at 1/500 dilution

    Lane 1 : SNX17 transfected 293T lysate
    Lane 2 : Non transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 53 kDa
    Observed band size : 53 kDa

Anti-SNX17 antibody (ab67599)参考文献

ab67599 has not yet been referenced specifically in any publications.

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