概述

  • 产品名称
  • 描述
    山羊多克隆抗体to SNX16
  • 特异性
    This antibody is expected to recognise all three human isoforms.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: ATPYVPVPMPIGN, corresponding to N terminal amino acids 2-14 of Human SNX16.

  • 常规说明
    Principal Names - SNX16; DKFZp666H147; sorting nexin 16 Official Gene Symbol - SNX16 (interim symbol) GenBank Accession Number – NP_071416; NP_690049; NP_690050 LocusLink ID - 64089 (human); 74718 (mouse); 64088 (rat) Gene Ontology terms - protein transporter activity; intracellular protein transport; intracellular signaling cascade; kinesin complex.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • 纯度
    IgG fraction
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab4151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.05 - 0.2 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 39 kDa).Can be blocked with Human SNX16 peptide (ab22994). In transfected HEK293 transiently expressing SNX16 a band of approx. 40kDa is observed. This band is not observed in the non-transfected HEK293.

靶标

  • 功能
    May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
  • 组织特异性
    Detected in placenta, lung, liver,heart and pancreas.
  • 序列相似性
    Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
  • 结构域
    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • 细胞定位
    Early endosome membrane. Late endosome membrane. Cytoplasm. Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp666H147 antibody
    • OTTHUMP00000227313 antibody
    • OTTHUMP00000227314 antibody
    • SNX16 antibody
    • SNX16_HUMAN antibody
    • Sorting nexin-16 antibody
    see all

图片

实验方案

文献

ab4151 has not yet been referenced specifically in any publications.

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