The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.05 - 0.2 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 39 kDa).Can be blocked with Human SNX16 peptide (ab22994). In transfected HEK293 transiently expressing SNX16 a band of approx. 40kDa is observed. This band is not observed in the non-transfected HEK293.
功能May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
组织特异性Detected in placenta, lung, liver,heart and pancreas.
序列相似性Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.
结构域The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
细胞定位Early endosome membrane. Late endosome membrane. Cytoplasm. Lysosome.