概述

  • 产品名称Anti-SNTB2抗体
    参阅全部 SNTB2 一抗
  • 描述
    兔多克隆抗体to SNTB2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Monkey
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 174 - 538 of Human SNTB2

  • 阳性对照
    • 293T, A431, H1299, HeLa, HepG2 and Raji cells. OVCAR3 xenograft.

性能

应用

Our Abpromise guarantee covers the use of ab96295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
  • 组织特异性Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
  • 序列相似性Belongs to the syntrophin family.
    Contains 1 PDZ (DHR) domain.
    Contains 2 PH domains.
    Contains 1 SU (syntrophin unique) domain.
  • 结构域The PH 1 domain mediates the oligomerization in a calcium dependent manner.
    The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
    The SU domain binds calmodulin in a calcium-dependent manner.
  • 翻译后修饰Phosphorylated. Partially dephosphorylated upon insulin stimulation.
  • 细胞定位Membrane. Cytoplasmic vesicle > secretory vesicle membrane. Cell junction. Cytoplasm > cytoskeleton. Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Syntrophin like antibody
    • 59 kDa dystrophin associated protein A1 basic component 2 antibody
    • 59 kDa dystrophin-associated protein A1 basic component 2 antibody
    • Basic beta 2 syntrophin antibody
    • Beta 2 syntrophin antibody
    • Beta-2-syntrophin antibody
    • D16S2531E antibody
    • Dystrophin associated protein A1 59kD basic component 2 antibody
    • EST25263 antibody
    • SNT2B2 antibody
    • SNT3 antibody
    • Sntb2 antibody
    • SNTB2_HUMAN antibody
    • SNTL antibody
    • Syntrophin 3 antibody
    • Syntrophin beta 2 (dystrophin associated protein A1 59kDa basic component 2) antibody
    • Syntrophin-3 antibody
    • Syntrophin-like antibody
    see all

Anti-SNTB2 antibody 图像

  • Anti-SNTB2 antibody (ab96295) at 1/3000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 58 kDa
  • ab96295, at 1/500 dilution, staining SNTB2 in paraffin-embedded OVCAR3 xenograft

Anti-SNTB2 antibody (ab96295)参考文献

ab96295 has not yet been referenced specifically in any publications.

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