Anti-SNAP25 (phospho S187)抗体(ab169871)
Key features and details
- Rabbit polyclonal to SNAP25 (phospho S187)
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-SNAP25 (phospho S187)抗体
参阅全部 SNAP25 一抗 -
描述
兔多克隆抗体to SNAP25 (phospho S187) -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Mouse, Guinea pig, Human, Non human primates, Zebrafish -
免疫原
Synthetic peptide within Rat SNAP25 (phospho S187). The exact sequence is proprietary. Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser187 conjugated to KLH
Database link: P60881 -
阳性对照
- Rat hippocampal lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.50
Constituents: 50% Glycerol, 0.88% Sodium chloride, 0.01% BSA, 0.24% HEPES -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab169871于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Predicted molecular weight: 23 kDa.
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说明 |
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WB
1/1000. Predicted molecular weight: 23 kDa. |
靶标
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功能
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. -
组织特异性
Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum. -
序列相似性
Belongs to the SNAP-25 family.
Contains 2 t-SNARE coiled-coil homology domains. -
翻译后修饰
Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. -
细胞定位
Cytoplasm > perinuclear region. Cell membrane. Cell junction > synapse > synaptosome. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. - Information by UniProt
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数据库链接
- Entrez Gene: 6616 Human
- Entrez Gene: 20614 Mouse
- Entrez Gene: 25012 Rat
- Entrez Gene: 30712 Zebrafish
- Omim: 600322 Human
- SwissProt: P60880 Human
- SwissProt: P60879 Mouse
- SwissProt: P60881 Rat
see all -
别名
- bA416N4.2 antibody
- Bdr antibody
- CMS18 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab169871 被引用在 2 文献中.
- Fan S et al. Ceftriaxone Suppresses Group II Metabotropic Glutamate Receptor Expression Contributing to Reversal of Recognition Memory Deficits of Amyloid Precursor Protein/Presenilin 1 AD Mice. Front Neurosci 16:905403 (2022). PubMed: 35860293
- Wang X et al. Phosphorylated SNAP25 in the CA1 regulates morphine-associated contextual memory retrieval via increasing GluN2B-NMDAR surface localization. Addict Biol 23:1067-1078 (2018). PubMed: 28884870