The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SNAP25 antibody (ab31281)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Resistance to inhibitors of cholinesterase 4 homolog
Synaptosomal associated 25 kDa protein
Synaptosomal associated protein
Synaptosomal associated protein 25
Synaptosomal associated protein 25kDa
Synaptosomal-associated 25 kDa protein
Synaptosomal-associated protein 25
Synaptosomal-associated protein, 25-KD
功能t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
组织特异性Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
序列相似性Belongs to the SNAP-25 family. Contains 2 t-SNARE coiled-coil homology domains.
翻译后修饰Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association.
细胞定位Cytoplasm > perinuclear region. Cell membrane. Cell junction > synapse > synaptosome. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.