Anti-SNAP25 Interacting Protein抗体(ab111343)

概述

  • 产品名称Anti-SNAP25 Interacting Protein抗体
  • 描述
    兔多克隆抗体to SNAP25 Interacting Protein
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal region of Human SNAP25 Interacting Protein.

  • 阳性对照
    • HepG2 and HeLa cell extracts.

性能

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应用

Our Abpromise guarantee covers the use of ab111343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 112 kDa.

靶标

  • 功能Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • 组织特异性Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • 序列相似性Belongs to the SRCIN1 family.
  • 翻译后修饰Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
  • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Cell projection > axon. Cell projection > dendrite. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • p130Cas associated protein antibody
    • p130Cas-associated protein antibody
    • P140 antibody
    • p140Cap antibody
    • SNAP-25-interacting protein antibody
    • SNIP antibody
    • SRC kinase signaling inhibitor 1 antibody
    • SRCIN1 antibody
    • SRCN1_HUMAN antibody
    see all

Anti-SNAP25 Interacting Protein antibody 图像

  • All lanes : Anti-SNAP25 Interacting Protein antibody (ab111343) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HepG2 cell extract
    Lane 3 : HepG2 cell extract with immunizing peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 112 kDa

Anti-SNAP25 Interacting Protein antibody (ab111343)参考文献

ab111343 has not yet been referenced specifically in any publications.

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