产品名称 Anti-SMURF1抗体 参阅全部 SMURF1 一抗
特异性 This antibody is expected to recognise both reported isoforms (NP_065162.1 and NP_851994.1).
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PSEGSLEDEELPAQ , corresponding to Internal sequence amino acids 359-372 of Human SMURF1
Whole cell lysate prepared from human lung carcinoma cells.
存放说明 Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
存储溶液 Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris saline, pH 7.3
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纯度 Immunogen affinity purified
纯化说明 Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Immunizing Peptide (Blocking)
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
功能 E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
通路 Protein modification; protein ubiquitination.
序列相似性 Contains 1 C2 domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 2 WW domains.
翻译后修饰 Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
Information by UniProt
E3 ubiquitin-protein ligase SMURF1 antibody
Anti-SMURF1 antibody (ab40823)参考文献
has not yet been referenced specifically in any publications.
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