功能G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
序列相似性Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.
ab113438 at 10 µg/ml staining Smoothened in Human lung by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
Western blot - Smoothened antibody (ab113438)
All lanes : Anti-Smoothened antibody (ab113438) at 1/500 dilution
Lane 1 : Extracts from HuvEc cells Lane 2 : Extracts from HuvEc cells with Synthesized peptide
Predicted band size : 86 kDa
Anti-Smoothened antibody (ab113438)参考文献
This product has been referenced in:
Stathis A et al. Phase I trial of the oral smoothened inhibitor sonidegib in combination with paclitaxel in patients with advanced solid tumors. Invest New DrugsN/A:N/A (2017).
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