概述

  • 产品名称
    Anti-Smoothened抗体
    参阅全部 Smoothened 一抗
  • 描述
    兔多克隆抗体to Smoothened
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide against N terminal of Human Smoothened conjugated to KLH.

  • 阳性对照
    • Human Liver & lung tissue, HuvEc cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab113438 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 86 kDa.
ELISA 1/10000.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能
    G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
  • 序列相似性
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Frizzled family member 11 antibody
    • FZD11 antibody
    • Gx antibody
    • Gx protein antibody
    • Protein Gx antibody
    • SMO antibody
    • SMO_HUMAN antibody
    • SMOH antibody
    • Smoothened frizzled family receptor antibody
    • Smoothened homolog (Drosophila) antibody
    • Smoothened homolog antibody
    • Smoothened homolog precursor (SMO) (Gx protein) antibody
    • Smoothened seven transmembrane spanning receptor antibody
    see all

Anti-Smoothened antibody 图像

  • ab113438 at 10 µg/ml staining Smoothened in Human liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab113438 at 10 µg/ml staining Smoothened in Human lung by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • All lanes : Anti-Smoothened antibody (ab113438) at 1/500 dilution

    Lane 1 : Extracts from HuvEc cells
    Lane 2 : Extracts from HuvEc cells with Synthesized peptide


    Predicted band size : 86 kDa

Anti-Smoothened antibody (ab113438)参考文献

This product has been referenced in:
  • Stathis A  et al. Phase I trial of the oral smoothened inhibitor sonidegib in combination with paclitaxel in patients with advanced solid tumors. Invest New Drugs N/A:N/A (2017). Read more (PubMed: 28317088) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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