概述

  • 产品名称Anti-Smek1抗体
    参阅全部 Smek1 一抗
  • 描述
    兔多克隆抗体to Smek1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within C terminal amino acids 770-820 of Human Smek1 (NP_115949.3)

  • 阳性对照
    • Human Breast Carcinoma, Human Colon Carcinoma, Human Lung Adenocarcinoma, Human Non-Small Cell Lung Cancer, Human Placenta, Human Prostate Carcinoma, Human Stomach Adenocarcinoma, Human Testicular Seminoma, Mouse Renal Cell Carcinoma, Mouse Teratoma

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab91618 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
    • 序列相似性Belongs to the SMEK family.
      Contains 1 WH1 domain.
    • 细胞定位Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLFL1 antibody
      • KIAA2010 antibody
      • MEK1 SUPPRESSOR 1 antibody
      • MSTP033 antibody
      • P4R3A_HUMAN antibody
      • PP4R3 ALPHA antibody
      • PP4R3A antibody
      • PPP4R3A antibody
      • PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA antibody
      • Serine/threonine-protein phosphatase 4 regulatory subunit 3A antibody
      • SMEK homolog 1 antibody
      • SMEK homolog 1, suppressor of mek1 (Dictyostelium) antibody
      • smek1 antibody
      • SMK1 antibody
      see all

    Anti-Smek1 antibody 图像

    • ab91618, at 1/250 dilution, staining Smek1 in formalin-fixed paraffin-embedded Human stomach carcinoma tissue by Immunohistochemistry using DAB staining.
    • ab91618, at 1/250 dilution, staining Smek1 in formalin-fixed paraffin-embedded Human colon carcinoma tissue by Immunohistochemistry using DAB staining.
    • ab91618, at 1/250 dilution, staining Smek1 in formalin-fixed paraffin-embedded Mouse teratoma tissue by Immunohistochemistry using DAB staining.
    • ab91618, at 1/250 dilution, staining Smek1 in formalin-fixed paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry using Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.

    Anti-Smek1 antibody (ab91618)参考文献

    ab91618 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"