Anti-SMC6L1抗体(ab86103)

概述

  • 产品名称Anti-SMC6L1抗体
    参阅全部 SMC6L1 一抗
  • 描述
    兔多克隆抗体to SMC6L1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region between residue 1050 and the C-terminus (residue 1091) of Human SMC6L1 (Swiss-Prot Q96SB8)

  • 阳性对照
    • Human ovarian and breast tumor tissues.

性能

应用

Our Abpromise guarantee covers the use of ab86103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.
    • 组织特异性Widely expressed. Overexpressed in testis.
    • 序列相似性Belongs to the SMC family. SMC6 subfamily.
    • 结构域The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.
    • 翻译后修饰Sumoylated by NSMCE2/MMS21.
      Ubiquitinated.
    • 细胞定位Nucleus. Chromosome. Chromosome > telomere. Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ22116 antibody
      • FLJ35534 antibody
      • hSMC6 antibody
      • SMC 6 antibody
      • SMC protein 6 antibody
      • SMC-6 antibody
      • SMC6 antibody
      • SMC6 protein antibody
      • SMC6 structural maintenance of chromosomes 6 like 1 antibody
      • SMC6_HUMAN antibody
      • Smc6l1 antibody
      • Structural maintenance of chromosomes 6 antibody
      • Structural maintenance of chromosomes 6 like 1 antibody
      • Structural maintenance of chromosomes protein 6 antibody
      see all

    Anti-SMC6L1 antibody 图像

    • ab86103, at 1/250 dilution, staining SMC6L1 in formalin-fixed, paraffin-embedded human ovarian tumor tissue by Immunohistochemistry using DAB staining.
    • ab86103, at 1/250 dilution, staining SMC6L1 in formalin-fixed, paraffin-embedded human breast tumor tissue by Immunohistochemistry using DAB staining.

    Anti-SMC6L1 antibody (ab86103)参考文献

    ab86103 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunocytochemistry/ Immunofluorescence
    Sample Human Cell (HeLa)
    Specification HeLa
    Permeabilization Yes - 0.5% Triton X100 in PBS
    Fixative Paraformaldehyde
    Username

    Dr. Kirk McManus

    Verified customer

    提交于 Nov 15 2013

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"