概述

  • 产品名称Anti-SMC6L1抗体
    参阅全部 SMC6L1 一抗
  • 描述
    小鼠单克隆抗体to SMC6L1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-110 of Human SMC6L1

性能

应用

Our Abpromise guarantee covers the use of ab57759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.
    • 组织特异性Widely expressed. Overexpressed in testis.
    • 序列相似性Belongs to the SMC family. SMC6 subfamily.
    • 结构域The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.
    • 翻译后修饰Sumoylated by NSMCE2/MMS21.
      Ubiquitinated.
    • 细胞定位Nucleus. Chromosome. Chromosome > telomere. Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ22116 antibody
      • FLJ35534 antibody
      • hSMC6 antibody
      • SMC 6 antibody
      • SMC protein 6 antibody
      • SMC-6 antibody
      • SMC6 antibody
      • SMC6 protein antibody
      • SMC6 structural maintenance of chromosomes 6 like 1 antibody
      • SMC6_HUMAN antibody
      • Smc6l1 antibody
      • Structural maintenance of chromosomes 6 antibody
      • Structural maintenance of chromosomes 6 like 1 antibody
      • Structural maintenance of chromosomes protein 6 antibody
      see all

    Anti-SMC6L1 antibody 图像

    • SMC6L1 antibody (ab57759) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.


    • Predicted band size : 126 kDa
      SMC6L1 antibody (ab57759) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-SMC6L1 antibody (ab57759)参考文献

    ab57759 has not yet been referenced specifically in any publications.

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