概述

  • 产品名称Anti-SMC2抗体
    参阅全部 SMC2 一抗
  • 描述
    山羊多克隆抗体to SMC2
  • 特异性Reported variants NP_006435.2, NP_001036015.1 and NP_001036016.1 represent identical protein and therefore should be recognized.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    SKAKPPKGAHVEV

    with a Cysteine residue linker, corresponding to C terminal amino acids 1185-1197 of Human SMC2 (NP_006435.2).

  • 阳性对照
    • HeLa lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab116611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.2 - 0.6 µg/ml. Predicted molecular weight: 136 kDa.

靶标

  • 功能Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 序列相似性Belongs to the SMC family. SMC2 subfamily.
  • 结构域The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.
  • 细胞定位Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAP E antibody
    • CAPE antibody
    • Chromosome associated protein E antibody
    • Chromosome-associated protein E antibody
    • FLJ10093 antibody
    • hCAP E antibody
    • hCAP-E antibody
    • hCAPE antibody
    • PRO0324 antibody
    • SMC 2 antibody
    • SMC protein 2 antibody
    • SMC-2 antibody
    • SMC2 antibody
    • SMC2 L1 antibody
    • SMC2_HUMAN antibody
    • SMC2L1 antibody
    • Structural maintenance of chromosomes (SMC) family member chromosome associated protein E antibody
    • Structural maintenance of chromosomes 2 antibody
    • Structural maintenance of chromosomes 2 like 1 antibody
    • Structural maintenance of chromosomes 2 yeast like 1 antibody
    • Structural maintenance of chromosomes protein 2 antibody
    • XCAP E homolog antibody
    • XCAP-E homolog antibody
    • XCAPE homolog antibody
    see all

Anti-SMC2 antibody 图像

  • Anti-SMC2 antibody (ab116611) at 0.2 µg/ml + HeLa cell lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 136 kDa

Anti-SMC2 antibody (ab116611)参考文献

ab116611 has not yet been referenced specifically in any publications.

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