Anti-SMARCD3抗体(ab50556)

概述

• 产品名称
  Anti-SMARCD3抗体
  参阅全部 SMARCD3 一抗
• 描述
  兔多克隆抗体to SMARCD3
• 特异性
  This antibody reacts with SMARCD3
• 经测试应用
  适用于: WB, ELISAmore details
• 种属反应性
  与反应: Mouse, Human
  预测可用于: Rat, Cow, Dog, Zebrafish
• 免疫原

  A region within synthetic peptide: FERKLDQTIM RKRVDIQEAL KRPMKQKRKL RLYISNTFNP AKPDAEDSDG, corresponding to amino acids 128-177 of Human SMARCD3

  Run BLAST with Run BLAST with
• 阳性对照
  • 293T cell lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Chromatin Remodeling
  • Swi / Snf

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol II Transcription
  • Other

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Cardiovascular
  • Heart
  • Cardiogenesis
  • Transcription factors/regulators

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
• 组织特异性
  Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
• 序列相似性
  Belongs to the SMARCD family.
  Contains 1 SWIB domain.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession Q6STE5 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 777769 Cow
  • Entrez Gene: 6604 Human
  • Entrez Gene: 66993 Mouse
  • Entrez Gene: 296732 Rat
  • Omim: 601737 Human
  • SwissProt: Q6STE5 Human
  • SwissProt: Q6P9Z1 Mouse
  • Unigene: 647067 Human

  • Unigene: 436539 Mouse
  • Unigene: 20043 Rat

  see all
• 别名
  • 60 kDa BRG 1/Brm associated factor subunit C antibody
  • 60 kDa BRG-1/Brm-associated factor subunit C antibody
  • BAF60C antibody

  • BRG1 associated factor 60C antibody
  • BRG1-associated factor 60C antibody
  • Chromatin remodeling complex BAF60C subunit antibody
  • CRACD3 antibody
  • Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody
  • MGC111010 antibody
  • Rsc6p antibody
  • Smarcd3 antibody
  • SMRD3_HUMAN antibody
  • SWI/SNF complex 60 kDa subunit C antibody
  • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody
  • Swp73 like protein antibody

  see all

实验方案

• Western blot protocols