概述

  • 产品名称Anti-SmarcAL1抗体
    参阅全部 SmarcAL1 一抗
  • 描述
    兔多克隆抗体to SmarcAL1
  • 特异性Human SmarcAL1
  • 经测试应用适用于: WB, IHC-P, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: SNADQRPHDSHSFQAKG conjugated to KLH, corresponding to amino acids 80-96 of Human SmarcAL1 (NP_054859.2).

  • 阳性对照
    • Human Brain Cortex tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 0.27% Potassium phosphate, 0.88% Sodium chloride
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 106 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA 1/16000 - 1/64000.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA.
  • 组织特异性Ubiquitously expressed, with high levels in testis.
  • 疾病相关Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD) [MIM:242900]. SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema.
  • 序列相似性Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
    Contains 2 HARP domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HARP antibody
    • HepA Related Protein antibody
    • HepA-related protein antibody
    • hHARP antibody
    • SIOD antibody
    • SMAL1_HUMAN antibody
    • SMARCA like Protein 1 antibody
    • smarcal1 antibody
    • Sucrose nonfermenting protein 2 like 1 antibody
    • Sucrose nonfermenting protein 2-like 1 antibody
    • SWI/SNF Related antibody
    • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A like protein 1 antibody
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 antibody
    see all

Anti-SmarcAL1 antibody 图像

  • ab115611, at 5µg/ml, staining SmarcAL1 in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SmarcAL1 antibody (ab115611)参考文献

ab115611 has not yet been referenced specifically in any publications.

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