Anti-SMARCA2 / BRM抗体(ab58188)

概述

  • 产品名称Anti-SMARCA2 / BRM抗体
    参阅全部 SMARCA2 / BRM 一抗
  • 描述
    小鼠单克隆抗体to SMARCA2 / BRM
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: KILLDPNSEE VSEKDAKQII ETAKQDVDDE YSMQYSARGS QSYYTVAHAI SERVEKQSAL LINGTLKHYQ LQGLEWM, corresponding to amino acids 659-736 of Human SMARCA2/ BRM

性能

应用

Our Abpromise guarantee covers the use of ab58188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 疾病相关Nicolaides-Baraitser syndrome
  • 序列相似性Belongs to the SNF2/RAD54 helicase family.
    Contains 1 bromo domain.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
    Contains 1 HSA domain.
    Contains 1 QLQ domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ATP dependent helicase SMARCA2 antibody
    • ATP-dependent helicase SMARCA2 antibody
    • BAF190 antibody
    • BAF190B antibody
    • BRG1-associated factor 190B antibody
    • BRM antibody
    • FLJ36757 antibody
    • Global transcription activator homologous sequence antibody
    • hBRM antibody
    • hSNF2a antibody
    • MGC74511 antibody
    • Possible global transcription activator SNF2L2 antibody
    • Probable global transcription activator SNF2L2 antibody
    • Protein brahma homolog antibody
    • SMARCA2 antibody
    • SMCA2_HUMAN antibody
    • SNF2 alpha antibody
    • SNF2 like 2 antibody
    • SNF2-alpha antibody
    • SNF2/SWI2 like protein 2 antibody
    • SNF2L2 antibody
    • SNF2LA antibody
    • Sth1p antibody
    • Sucrose nonfermenting 2 like protein 2 antibody
    • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 antibody
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 antibody
    see all

Anti-SMARCA2 / BRM antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab58188 SMARCA2 / BRM antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

Anti-SMARCA2 / BRM antibody (ab58188)参考文献

ab58188 has not yet been referenced specifically in any publications.

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