Anti-SMAD6抗体- Carboxyterminal end (ab80049)

概述

  • 产品名称Anti-SMAD6抗体- Carboxyterminal end
    参阅全部 SMAD6 一抗
  • 描述
    兔多克隆抗体to SMAD6 - Carboxyterminal end
  • 特异性This reacts specifically with human 54 kDa SMAD6 isoform D protein. It is not expected to cross react with other species.
  • 经测试应用适用于: IHC-P, IHC-Fr, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from the C terminal domain of SMAD6 Isoform D

性能

应用

Our Abpromise guarantee covers the use of ab80049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
IHC-Fr 1/100 - 1/500.
WB 1/500 - 1/5000. Predicted molecular weight: 53 kDa.

靶标

  • 功能Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.
  • 组织特异性Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
  • 序列相似性Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • 翻译后修饰Phosphorylated by BMP type 1 receptor kinase and by PRKX.
    Ubiquitinated by WWP1.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hSMAD6 antibody
    • MAD homolog 6 antibody
    • MADH6 antibody
    • MADH7 antibody
    • Mothers against decapentaplegic homolog 6 antibody
    • Mothers against DPP homolog 6 antibody
    • SMAD 6 antibody
    • SMAD family member 6 antibody
    • SMAD mothers against DPP homolog 6 antibody
    • Smad6 antibody
    • SMAD6_HUMAN antibody
    see all

Anti-SMAD6 antibody - Carboxyterminal end (ab80049)参考文献

ab80049 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80049.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"