Anti-SMAD6抗体(ab80049)
Key features and details
- Rabbit polyclonal to SMAD6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-SMAD6抗体
参阅全部 SMAD6 一抗 -
描述
兔多克隆抗体to SMAD6 -
宿主
Rabbit -
特异性
This reacts specifically with human 54 kDa SMAD6 isoform D protein. It is not expected to cross react with other species. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide derived from the C terminal domain of SMAD6 Isoform D
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
-
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab80049于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/5000. Predicted molecular weight: 53 kDa.
|
说明 |
---|
WB
1/500 - 1/5000. Predicted molecular weight: 53 kDa. |
靶标
-
功能
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. -
组织特异性
Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. -
序列相似性
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain. -
翻译后修饰
Phosphorylated by BMP type 1 receptor kinase and by PRKX.
Ubiquitinated by WWP1. -
细胞定位
Nucleus. - Information by UniProt
-
数据库链接
- Entrez Gene: 4091 Human
- Omim: 602931 Human
- SwissProt: O43541 Human
- Unigene: 153863 Human
-
别名
- hSMAD6 antibody
- MAD homolog 6 antibody
- MADH6 antibody
see all
数据表及文件
-
Datasheet download
文献 (9)
ab80049 被引用在 9 文献中.
- Zhang M et al. The Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas. Front Cell Dev Biol 9:670145 (2021). PubMed: 34079802
- Wang H & Ji X SMAD6, positively regulated by the DNM3OS-miR-134-5p axis, confers promoting effects to cell proliferation, migration and EMT process in retinoblastoma. Cancer Cell Int 20:23 (2020). PubMed: 31992960
- Mi B et al. Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6. J Nanobiotechnology 18:68 (2020). PubMed: 32375794
- Li M et al. GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation. Elife 9:N/A (2020). PubMed: 33006314
- Yang P et al. Construction and Investigation of MicroRNA-mRNA Regulatory Network of Gastric Cancer with Helicobacter pylori Infection. Biochem Res Int 2020:6285987 (2020). PubMed: 32802507
- He S et al. Circular RNA hsa_circ_0000517 modulates hepatocellular carcinoma advancement via the miR-326/SMAD6 axis. Cancer Cell Int 20:360 (2020). PubMed: 32774154
- Xu S & Wu X miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6. Biosci Rep 39:N/A (2019). PubMed: 30135141
- Park JS et al. RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31690042
- Piacentino ML & Bronner ME Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction. PLoS Biol 16:e2004425 (2018). PubMed: 29949573