Anti-Smad1 (phospho S206)抗体(ab106092)

概述

  • 产品名称
    Anti-Smad1 (phospho S206)抗体
    参阅全部 Smad1 一抗
  • 描述
    兔多克隆抗体to Smad1 (phospho S206)
  • 特异性
    ab106092 is specific for Smad1 phosphorylated pS206. Reactivity with nonphosphorylated human Smad1 is minimal by ELISA and western blot. Espected to recognize Smad1 from Duckbill platypus, bonobo, salmon due to 100% immunogen seqeunce homology.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Sheep, Chicken, Cow, Dog, Pig, Chimpanzee, Drosophila melanogaster, Macaque monkey, Gorilla, Opossum, Orangutan
  • 免疫原

    A phosphorylated synthetic peptide corresponding to amino acids surrounding serine 206 of Human Smad1.

  • 阳性对照
    • HEPG2 and HaCaT whole cell lysates, treated with BMP2, EGF, or NaCl.
  • 常规说明
    Expiration date is one year from date of opening. Dilute only prior to immediate use.

性能

应用

Our Abpromise guarantee covers the use of ab106092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 52 kDa.

靶标

  • 功能
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
  • 组织特异性
    Ubiquitous. Highest expression seen in the heart and skeletal muscle.
  • 序列相似性
    Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • 翻译后修饰
    Phosphorylated on serine by BMP type 1 receptor kinase.
    Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
  • 细胞定位
    Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BSP-1 antibody
    • BSP1 antibody
    • HsMAD1 antibody
    • JV4-1 antibody
    • JV41 antibody
    • MAD homolog 1 antibody
    • MAD mothers against decapentaplegic homolog 1 antibody
    • Mad related protein 1 antibody
    • Mad-related protein 1 antibody
    • MADH1 antibody
    • MADR1 antibody
    • Mothers against decapentaplegic homolog 1 antibody
    • Mothers against DPP homolog 1 antibody
    • SMA- AND MAD-RELATED PROTEIN 1 antibody
    • SMAD 1 antibody
    • SMAD family member 1 antibody
    • SMAD mothers against DPP homolog 1 antibody
    • Smad1 antibody
    • SMAD1_HUMAN antibody
    • TGF beta signaling protein 1 antibody
    • Transforming growth factor-beta-signaling protein 1 antibody
    see all

实验方案

文献

ab106092 has not yet been referenced specifically in any publications.

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