Anti-SLPI抗体[31] (ab17157)
Key features and details
- Mouse monoclonal [31] to SLPI
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
Anti-SLPI抗体[31]
参阅全部 SLPI 一抗 -
描述
小鼠单克隆抗体[31] to SLPI -
宿主
Mouse -
特异性
The reactivity of the antibody with the isolated domains was evaluated using isolated domains of SLPI obtained by cleavage using partial acidic hydrolysis. Therefore, it is possible that the antibody will recognize other SLPI cleavage products generated by e.g. (microbial) proteases. -
经测试应用
适用于: IHC-Frmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human SLPI. SLPI purified from sputum
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阳性对照
- PMN lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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克隆
单克隆 -
克隆编号
31 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab17157于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-Fr |
1/50.
|
说明 |
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IHC-Fr
1/50. |
靶标
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功能
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. -
组织特异性
Mucous fluids. -
序列相似性
Contains 2 WAP domains. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 6590 Human
- GenBank: NM_003064 Human
- Omim: 107285 Human
- SwissProt: P03973 Human
- Unigene: 517070 Human
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别名
- ALK 1 antibody
- ALK1 antibody
- ALP antibody
see all
数据表及文件
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Datasheet download
文献 (6)
ab17157 被引用在 6 文献中.
- Wei Z et al. Inhibition of secretory leukocyte protease inhibitor (SLPI) promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells. Discov Oncol 14:1 (2023). PubMed: 36595102
- McElvaney OF et al. Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications. EBioMedicine 77:103894 (2022). PubMed: 35217407
- Huang Y et al. Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps. J Immunol Res 2021:1057186 (2021). PubMed: 33506054
- Jin Y et al. Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-?B and Akt pathways. Cancer Cell Int 19:220 (2019). PubMed: 31462893
- Xu CB et al. microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor ß1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor. J Cell Biochem N/A:N/A (2019). PubMed: 30706537
- Wang X et al. Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep 39:1793-1804 (2018). PubMed: 29436667