概述

  • 产品名称
    Anti-Slitrk1抗体
    参阅全部 Slitrk1 一抗
  • 描述
    兔多克隆抗体to Slitrk1
  • 特异性
    This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
  • 经测试应用
    适用于: WB, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 16 amino acid peptide from near the carboxy terminus of human Slitrk1.

  • 阳性对照
    • Human brain tissue lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 88 kDa (predicted molecular weight: 78 kDa).
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.

靶标

  • 相关性
    Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.
  • 细胞定位
    Membrane; Single-pass type I membrane protein
  • 数据库链接
  • 别名
    • SLITRK1 antibody
    • FLJ54428 antibody
    • KIAA0918 antibody
    • KIAA1910 antibody
    • Leucine rich repeat containing protein 12 antibody
    • LRRC1 antibody
    • LRRC12 antibody
    • RP11-395N17.1 antibody
    • SLIT and NTRK like family, member 1 antibody
    • SLIT and NTRK-like protein 1 antibody
    • slit and trk like gene 1 antibody
    • SLITRK 1 antibody
    • TTM antibody
    • UNQ233/PRO266 antibody
    see all

Anti-Slitrk1 antibody 图像

  • Immunofluorescence of Slitrk1 in Human brain tissue with ab67238 at 20 ug/mL.

  • Immunohistochemistry of Slitrk1 in Human brain tissue with Slitrk1 antibody at 2.5 μg/mL.

  • Lane 1 : Anti-Slitrk1 antibody (ab67238) at 1 µg/ml
    Lane 2 : Anti-Slitrk1 antibody (ab67238) at 2 µg/ml

    Lane 1 : human brain tissue lysate
    Lane 2 : human brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 78 kDa
    Observed band size : 88 and 60 kDa (why is the actual band size different from the predicted?)

Anti-Slitrk1 antibody (ab67238)参考文献

ab67238 has not yet been referenced specifically in any publications.

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