概述

  • 产品名称Anti-SLC34A2抗体
    参阅全部 SLC34A2 一抗
  • 描述
    兔多克隆抗体to SLC34A2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: MRSLKPWDAV VSKFTGCFQM RCCCCCRVCC RACCLLCGCP KCCRCSKCCE DLEEAQEGQD VPVKAPETFD NITISREAQG EVPASDSKTE CT, corresponding to C terminal amino acids 597-688 of Human SLC34A2 protein (UniProt ID: O95436).

  • 阳性对照
    • Human lung tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab122431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
  • 组织特异性Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
  • 疾病相关Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM) [MIM:265100]. Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
  • 序列相似性Belongs to the SLC34A transporter family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Na(+)-dependent phosphate cotransporter 2B antibody
    • Na(+)/Pi cotransporter 2B antibody
    • NaPi-2b antibody
    • NaPi3b antibody
    • NPT2B_HUMAN antibody
    • SLC34A2 antibody
    • Sodium-dependent phosphate transport protein 2B antibody
    • Sodium-phosphate transport protein 2B antibody
    • Sodium/phosphate cotransporter 2B antibody
    • Solute carrier family 34 member 2 antibody
    see all

Anti-SLC34A2 antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling SLC34A2 with ab122431. Staining shows strong cytoplasmic positivity in pneumocytes.

Anti-SLC34A2 antibody (ab122431)参考文献

ab122431 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab122431.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"