概述

  • 产品名称
    Anti-SLC33A1抗体
    参阅全部 SLC33A1 一抗
  • 描述
    兔多克隆抗体to SLC33A1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 215-264 (CNSVGQTAGY FLGNVLFLAL ESADFCNKYL RFQPQPRGIV TLSDFLFFWG) of human SLC33A1 (NP_004724).

  • 阳性对照
    • Human Placenta lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab83868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.
  • 组织特异性
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
  • 疾病相关
    Spastic paraplegia autosomal dominant 42 (SPG42) [MIM:612539]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Congenital cataracts, hearing loss, and neurodegeneration (CCHLND) [MIM:614482]: An autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性
    Belongs to the SLC33A transporter family.
  • 细胞定位
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ACATN antibody
    • ACATN_HUMAN antibody
    • Acetyl CoA transporter antibody
    • Acetyl Coenzyme A transporter antibody
    • Acetyl coenzyme A transporter 1 antibody
    • Acetyl-CoA transporter 1 antibody
    • Acetyl-coenzyme A transporter 1 antibody
    • AT 1 antibody
    • AT-1 antibody
    • AT1 antibody
    • Human Angiotensin II Type 1 Receptor antibody
    • Slc33a1 antibody
    • Solute carrier family 33 (acetyl CoA transporter) member 1 antibody
    • Solute carrier family 33 member 1 antibody
    • spastic paraplegia 42 (autosomal dominant) antibody
    • SPG42 antibody
    see all

Anti-SLC33A1 antibody 图像

  • Anti-SLC33A1 antibody (ab83868) at 1 µg/ml (5% skim milk / PBS buffer) + Placenta lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 61 kDa
    Observed band size : 61 kDa

实验方案

Anti-SLC33A1 antibody (ab83868)参考文献

This product has been referenced in:
  • Liu P  et al. S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model. Dis Model Mech 10:53-62 (2017). WB . Read more (PubMed: 27935820) »

See 1 Publication for this product

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