概述

  • 产品名称Anti-SLC22A4抗体
    参阅全部 SLC22A4 一抗
  • 描述
    兔多克隆抗体to SLC22A4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 521-550 of Human SLC22A4 (NP_003050.2).

  • 阳性对照
    • HeLa cell line lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab107727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.

靶标

  • 功能Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
  • 组织特异性Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
  • 疾病相关Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ergothioneine transporter antibody
    • ET transporter antibody
    • integral membrane transport protein antibody
    • LSTP Like 2 antibody
    • MGC34546 antibody
    • MGC40524 antibody
    • Octn1 antibody
    • Organic cation transporter 1 antibody
    • Organic cation/carnitine transporter 1 antibody
    • RP23-354D12.1 antibody
    • S22A4_HUMAN antibody
    • Slc22a4 antibody
    • Solute carrier family (organic cation transporter), member 4 antibody
    • solute carrier family 22 (organic cation/zwitterion transporter), member 4 antibody
    • Solute carrier family 22 member 4 antibody
    see all

Anti-SLC22A4 antibody 图像

  • Anti-SLC22A4 antibody (ab107727) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 62 kDa

Anti-SLC22A4 antibody (ab107727)参考文献

This product has been referenced in:
  • Li RW  et al. Uptake and protective effects of ergothioneine in human endothelial cells. J Pharmacol Exp Ther 350:691-700 (2014). Human . Read more (PubMed: 25022513) »

See 1 Publication for this product

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