概述

  • 产品名称Anti-SLC22A17抗体
    参阅全部 SLC22A17 一抗
  • 描述
    兔多克隆抗体to SLC22A17
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide to a region within residues: CYQPVGGGGS PSDFYLCSLL ASGTAALACV FLGVTVDRFG RRGILLLSMT, corresponding to internal sequence amino acids 324-373 of Human SLC22A17 (NP_065105)

  • 阳性对照
    • DU145 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab90099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
  • 组织特异性Expressed in brain.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 细胞定位Cell membrane. Vacuole membrane. Upon LCN2-binding, it is internalized.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 24p3 receptor antibody
    • 24p3R antibody
    • BOCT antibody
    • BOIT antibody
    • Brain type organic cation transporter antibody
    • Brain-type organic cation transporter antibody
    • hBOIT antibody
    • Lipocalin-2 receptor antibody
    • Neutrophil gelatinase associated lipocalin receptor antibody
    • Neutrophil gelatinase-associated lipocalin receptor antibody
    • NGAL receptor antibody
    • NgalR antibody
    • NGALR2 antibody
    • NGALR3 antibody
    • OTTHUMP00000082690 antibody
    • OTTHUMP00000082691 antibody
    • Potent brain type organic ion transporter antibody
    • S22AH_HUMAN antibody
    • Slc22a17 antibody
    • Solute carrier family 22 member 17 antibody
    • Solute carrier family 22 organic cation transporter member 17 antibody
    see all

Anti-SLC22A17 antibody 图像

  • Anti-SLC22A17 antibody (ab90099) at 1 µg/ml (in 5% skim milk / PBS buffer) + DU145 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 58 kDa

Anti-SLC22A17 antibody (ab90099)参考文献

ab90099 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90099.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"