概述

  • 产品名称Anti-SLC22A12抗体
    参阅全部 SLC22A12 一抗
  • 描述
    兔多克隆抗体to SLC22A12
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: ESARWLLTTG RLDWGLQELW RVAAINGKGA VQDTLTPEVL LSAMREELSM GQPPASLGTL LRMPGLRFRT CI, corresponding to amino acids 281-352 of Human SLC22A12 (UniProt ID: Q96S37).

  • 阳性对照
    • WB: RT-4 and Human plasma IHC-P: Human kidney tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同���型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab121826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.
  • 组织特异性Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
  • 疾病相关Defects in SLC22A12 are a cause of renal hypouricemia (RH) [MIM:220150]. Patients have low serum urate levels, due to defects in renal urate re-absorption and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure (ARF), chronic renal dysfunction and uric acid urolithiasis.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 细胞定位Cell membrane. Detected in the luminal membrane of the epithelium of renal proximal tubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Organic anion transporter 4-like protein antibody
    • Renal-specific transporter antibody
    • RST antibody
    • S22AC_HUMAN antibody
    • Slc22a12 antibody
    • Solute carrier family 22 member 12 antibody
    • Urate anion exchanger 1 antibody
    see all

Anti-SLC22A12 antibody 图像

  • ab121826, at a 1/250 dilution, staining SLC22A12 in paraffin embedded Human kidney tissue by Immunohistochemistry.

Anti-SLC22A12 antibody (ab121826)参考文献

ab121826 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121826.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"