概述

  • 产品名称Anti-SLC22A1抗体
    参阅全部 SLC22A1 一抗
  • 描述
    兔多克隆抗体to SLC22A1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 510-539 of Human SLC22A1 (O15245, NP_003048.1, NP_694857.1).

  • 阳性对照
    • HepG2 cell line lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab123128 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab123128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

靶标

  • 功能Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 组织特异性Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Basolateral cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hOCT1 antibody
    • OCT1 antibody
    • oct1_cds antibody
    • Organic cation transporter 1 antibody
    • S22A1_HUMAN antibody
    • Slc22a1 antibody
    • solute carrier family 22 (organic cation transporter), member 1 antibody
    • Solute carrier family 22 member 1 antibody
    see all

Anti-SLC22A1 antibody 图像

  • Anti-SLC22A1 antibody (ab123128) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 61 kDa

Anti-SLC22A1 antibody (ab123128)参考文献

This product has been referenced in:
  • Hubeny A  et al. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metab Dispos 44:1562-8 (2016). Read more (PubMed: 27504015) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab123128.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"