Anti-SLC17A5抗体(ab69819)

概述

  • 产品名称Anti-SLC17A5抗体
    参阅全部 SLC17A5 一抗
  • 描述
    兔多克隆抗体to SLC17A5
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide (Human)

  • 阳性对照
    • Human skeletal muscle tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab69819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).Can be blocked with Human SLC17A5 peptide (ab178604). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

靶标

  • 功能Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
  • 组织特异性Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
  • 疾病相关Salla disease
    Infantile sialic acid storage disorder
  • 序列相似性Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
  • 细胞定位Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AST antibody
    • H(+)/nitrate cotransporter antibody
    • H(+)/sialic acid cotransporter antibody
    • ISSD antibody
    • Membrane glycoprotein HP59 antibody
    • NSD antibody
    • S17A5_HUMAN antibody
    • SD antibody
    • Sialic acid storage disease antibody
    • Sialin antibody
    • SIASD antibody
    • Slc17a5 antibody
    • SLD antibody
    • Solute carrier family 17 (anion/sugar transportermember 5 antibody
    • Solute carrier family 17 member 5 antibody
    • Vesicular H(+)/Aspartate-glutamate cotransporter antibody
    see all

Anti-SLC17A5 antibody 图像

  • Anti-SLC17A5 antibody (ab69819) at 0.5 µg/ml + Transfected 293T cell lysate at 10 µg with 5% skim milk / PBS buffer

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa
    Observed band size : 55 kDa
    Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemical analysis of paraffin embedded human muscle tissue labelled with ab69819 at 8 µg/ml. Positively labelled skeletal cells are indicated with arrows. Magnification 400X.

Anti-SLC17A5 antibody (ab69819)参考文献

ab69819 has not yet been referenced specifically in any publications.

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Thank you for contacting Abcam regarding ab69819.


The immunogen sequence is XXX.

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