功能Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
组织特异性Highly expressed in skeletal muscle.
序列相似性Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
形式Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 and MCT2, are characterized by 12 predicted transmembrane domains.
MCT 4 antibody
Monocarboxylate transporter 3 antibody
Monocarboxylate transporter 4 antibody
Solute carrier family 16 member 3 antibody
Anti-SLC16A3 antibody 图像
Western blot - SLC16A3 antibody (ab74109)
All lanes : Anti-SLC16A3 antibody (ab74109) at 1/500 dilution
Lane 1 : extracts from LOVO cells Lane 2 : extracts from LOVO cells with immunizing peptide at 5 µg
Lysates/proteins at 10 µg per lane.
Predicted band size : 49 kDa Observed band size : 49 kDa
Anti-SLC16A3 antibody (ab74109)参考文献
This product has been referenced in:
Ghorbel MT et al. Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury. BMC Genomics15:916 (2014).
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