概述

  • 产品名称Anti-SLC12A4抗体
    参阅全部 SLC12A4 一抗
  • 描述
    山羊多克隆抗体to SLC12A4
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    C-DPSHAPDNFRE

    , corresponding to internal sequence amino acids 995-1005 of Human SLC12A4 (NP_005063.1).

  • 阳性对照
    • Human Heart and Muscle lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99% Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab77340 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/4000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 121 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
    • 组织特异性Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
    • 序列相似性Belongs to the SLC12A transporter family.
    • 翻译后修饰N-glycosylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Electroneutral potassium chloride cotransporter 1 antibody
      • Electroneutral potassium-chloride cotransporter 1 antibody
      • Erythroid K Cl cotransporter 1 antibody
      • Erythroid K-Cl cotransporter 1 antibody
      • FLJ40489 antibody
      • hKCC 1 antibody
      • hKCC1 antibody
      • KCC 1 antibody
      • KCC1 antibody
      • Potassium transport protein antibody
      • Potassium/chloride cotransporter 1 antibody
      • S12A4_HUMAN antibody
      • Slc12a4 antibody
      • Solute carrier family 12 (potassium/chloride transporters) member 4 antibody
      • Solute carrier family 12 member 4 antibody
      see all

    Anti-SLC12A4 antibody 图像

    Anti-SLC12A4 antibody (ab77340)参考文献

    ab77340 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"