概述

  • 产品名称Anti-SLC12A4抗体
    参阅全部 SLC12A4 一抗
  • 描述
    山羊多克隆抗体to SLC12A4
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    DPSHAPDNFRE

    with a Cysteine residue linker, corresponding to internal sequence amino acids 995-1005 of Human SLC12A4 (NP_005063.1).

  • 阳性对照
    • Human Placenta tissue; Human heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab115607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/4000.
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 121 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
  • 组织特异性Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
  • 序列相似性Belongs to the SLC12A transporter family.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Electroneutral potassium chloride cotransporter 1 antibody
    • Electroneutral potassium-chloride cotransporter 1 antibody
    • Erythroid K Cl cotransporter 1 antibody
    • Erythroid K-Cl cotransporter 1 antibody
    • FLJ40489 antibody
    • hKCC 1 antibody
    • hKCC1 antibody
    • KCC 1 antibody
    • KCC1 antibody
    • Potassium transport protein antibody
    • Potassium/chloride cotransporter 1 antibody
    • S12A4_HUMAN antibody
    • Slc12a4 antibody
    • Solute carrier family 12 (potassium/chloride transporters) member 4 antibody
    • Solute carrier family 12 member 4 antibody
    see all

Anti-SLC12A4 antibody 图像

  • ab115607, at 5µg/ml, staining SLC12A4 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-SLC12A4 antibody (ab115607) at 0.3 µg/ml + Human heart lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 121 kDa

Anti-SLC12A4 antibody (ab115607)参考文献

ab115607 has not yet been referenced specifically in any publications.

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