概述

  • 产品名称Anti-SLC12A3抗体
    参阅全部 SLC12A3 一抗
  • 描述
    兔多克隆抗体to SLC12A3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    PGEPRKVRPTLADLHSFLKQEG

    , corresponding to N terminal amino acids 74-95 of Rat SLC12A3 (NP_062218)

  • 阳性对照
    • Rat kidney tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab95302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa).

靶标

  • 功能Electrically silent transporter system. Mediates sodium and chloride reabsorption.
  • 组织特异性Predominant in kidney.
  • 疾病相关Defects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.
  • 序列相似性Belongs to the SLC12A transporter family.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ96318 antibody
    • Na Cl cotransporter antibody
    • Na Cl symporter antibody
    • Na-Cl symporter antibody
    • NaCl electroneutral thiazide sensitive cotransporter antibody
    • NCC antibody
    • NCCT antibody
    • S12A3_HUMAN antibody
    • slc12a3 antibody
    • Solute carrier family 12 (sodium/chloride transporters) member 3 antibody
    • Solute carrier family 12 member 3 antibody
    • Thiazide sensitive Na Cl cotransporter antibody
    • Thiazide sensitive sodium chloride cotransporter antibody
    • Thiazide-sensitive sodium-chloride cotransporter antibody
    • TSC antibody
    see all

Anti-SLC12A3 antibody 图像

  • Immunofluorescent analysis of SLC12A3 in Rat kidney tissues using ab95302 at 1:200 dilution. DAPI merge.


  • Predicted band size : 111 kDa
    Western blot detection of SLC12A3 in Rat tissues using ab95302 at 1:1000 dilution.

Anti-SLC12A3 antibody (ab95302)参考文献

ab95302 has not yet been referenced specifically in any publications.

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