Anti-SLC12A3抗体(ab95302)
Key features and details
- Rabbit polyclonal to SLC12A3
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-SLC12A3抗体
参阅全部 SLC12A3 一抗 -
描述
兔多克隆抗体to SLC12A3 -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide:
PGEPRKVRPTLADLHSFLKQEG
, corresponding to N terminal amino acids 74-95 of Rat SLC12A3 (NP_062218) -
阳性对照
- Rat kidney tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
Preservative: 0.007% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95302于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/200.
|
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WB |
1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa).
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说明 |
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ICC/IF
1/200. |
WB
1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa). |
靶标
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功能
Electrically silent transporter system. Mediates sodium and chloride reabsorption. -
组织特异性
Predominant in kidney. -
疾病相关
Defects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome. -
序列相似性
Belongs to the SLC12A transporter family. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6559 Human
- Entrez Gene: 20497 Mouse
- Entrez Gene: 54300 Rat
- Omim: 600968 Human
- SwissProt: P55017 Human
- SwissProt: P59158 Mouse
- SwissProt: P55018 Rat
- Unigene: 669115 Human
see all -
别名
- FLJ96318 antibody
- Na Cl cotransporter antibody
- Na Cl symporter antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab95302 被引用在 6 文献中.
- Hanai S et al. Hypoxia-induced thyroid hormone receptor expression regulates cell-cycle progression in renal tubule epithelial cells. Endocr J 68:1309-1320 (2021). PubMed: 34108302
- Jobbagy S et al. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight 5:N/A (2020). PubMed: 31941842
- Wang LJ et al. PGF2a stimulates the 10-pS Cl- channel and thiazide-sensitive Na+-Cl- cotransporter in the distal convoluted tubule. Am J Physiol Renal Physiol 319:F414-F422 (2020). PubMed: 32715760
- Tang TT et al. Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Sci Adv 6:eaaz0748 (2020). PubMed: 32851154
- Zhang J et al. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet 24:4545-58 (2015). PubMed: 25994507
- Schumacher FR et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med 7:1285-306 (2015). PubMed: 26286618