概述

  • 产品名称
    Anti-Slap抗体
  • 描述
    兔多克隆抗体to Slap
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1-248 of Human Slap (AAH07042).

  • 阳性对照
    • 293T and A431 cell lysates

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab96620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 31 kDa.

靶标

  • 功能
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • 组织特异性
    Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
  • 序列相似性
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 结构域
    The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
  • 细胞定位
    Cytoplasm. Endosome. Colocalizes with endosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hSLAP antibody
    • SLA 1 antibody
    • sla antibody
    • SLA1 antibody
    • SLAP 1 antibody
    • SLAP antibody
    • SLAP-1 antibody
    • SLAP1 antibody
    • SLAP1_HUMAN antibody
    • Src like adapter antibody
    • Src like adapter protein 1 antibody
    • Src like adaptor antibody
    • SRC-like-adapter antibody
    • Src-like-adapter protein 1 antibody
    see all

图片

  • All lanes : Anti-Slap antibody (ab96620) at 1/2000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 31 kDa

实验方案

文献

ab96620 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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