概述

  • 产品名称Anti-SKA2抗体
    参阅全部 SKA2 一抗
  • 描述
    兔多克隆抗体to SKA2
  • 特异性ab75345 reacts specifically with SKA2 protein
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the C terminal domain of human SKA2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab75345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/200 - 1/2000. Predicted molecular weight: 14 kDa.

靶标

  • 功能Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.
  • 序列相似性Belongs to the SKA2 family.
  • 细胞定位Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FAM33A antibody
    • Family with sequence similarity 33, member A antibody
    • FLJ12758 antibody
    • MGC110975 antibody
    • Protein FAM33A antibody
    • SKA 2 antibody
    • SKA2 antibody
    • SKA2_HUMAN antibody
    • Spindle and kinetochore associated complex subunit 2 antibody
    • Spindle and kinetochore associated protein 2 antibody
    • Spindle and kinetochore-associated protein 2 antibody
    • Spindle and KT (kinetochore) associated 2 antibody
    • Spindle and KT associated 2 antibody
    see all

Anti-SKA2 antibody (ab75345)参考文献

ab75345 has not yet been referenced specifically in any publications.

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