概述

  • 产品名称Anti-SIRT2抗体
    参阅全部 SIRT2 一抗
  • 描述
    小鼠单克隆抗体to SIRT2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: YTQNIDTLER IAGLEQEDLV EAHGTFYTSH CVSASCRHEY PLSWMKEKIF SEVTPKCEDC QSLVKPDIVF FGESLPARFF SCMQSDFLKV DLLLVMGTSL , corresponding to amino acids 128-227 of Human SIR2/ SIRT2

性能

应用

Our Abpromise guarantee covers the use of ab56904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
    • 组织特异性Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
    • 序列相似性Belongs to the sirtuin family.
      Contains 1 deacetylase sirtuin-type domain.
    • 发展阶段Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
    • 翻译后修饰Phosphorylated at the G2/M transition of the cell cycle.
    • 细胞定位Cytoplasm > cytoskeleton. Colocalizes with microtubules.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ35621 antibody
      • FLJ37491 antibody
      • NAD dependent deacetylase sirtuin 2 antibody
      • NAD-dependent deacetylase sirtuin-2 antibody
      • NAD-dependent protein deacetylase sirtuin-2 antibody
      • Regulatory protein SIR2 homolog 2 antibody
      • Silencing information regulator 2 like antibody
      • Silent information regulator 2 antibody
      • SIR2 antibody
      • SIR2 like protein 2 antibody
      • Sir2 related protein type 2 antibody
      • SIR2, S. cerevisiae, homolog-loke 2 antibody
      • SIR2-like protein 2 antibody
      • SIR2L antibody
      • SIR2L2 antibody
      • SIRT2 antibody
      • SIRT2_HUMAN antibody
      • Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae) antibody
      • Sirtuin 2 antibody
      • Sirtuin type 2 antibody
      see all

    Anti-SIRT2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56904 SIR2 / SIRT2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    Anti-SIRT2 antibody (ab56904)参考文献

    ab56904 has not yet been referenced specifically in any publications.

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