Anti-Sin3b抗体(ab101841)
Key features and details
- Rabbit polyclonal to Sin3b
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Sin3b抗体
参阅全部 Sin3b 一抗 -
描述
兔多克隆抗体to Sin3b -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to a region within amino acids 165-325 of Human Sin3b.
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阳性对照
- HCT116 whole cell lysate and MCF7 xenograft tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab101841于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 133 kDa.
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IHC-P |
1/100 - 1/500.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 133 kDa. |
IHC-P
1/100 - 1/500. |
靶标
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功能
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. -
序列相似性
Contains 3 PAH (paired amphipathic helix) domains. -
翻译后修饰
Ubiquitinated by RNF220 that leads to proteasomal degradation. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 23309 Human
- Entrez Gene: 20467 Mouse
- Entrez Gene: 683381 Rat
- Omim: 607777 Human
- SwissProt: O75182 Human
- SwissProt: Q62141 Mouse
- SwissProt: Q3B8P8 Rat
- Unigene: 13999 Human
see all -
别名
- Histone deacetylase complex subunit Sin3b antibody
- Paired amphipathic helix protein Sin3b antibody
- SIN3 homolog B transcription regulator antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab101841 被引用在 1 文献中.
- Yang X et al. Coregulator Sin3a Promotes Postnatal Murine ß-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes 69:1219-1231 (2020). PubMed: 32245798