概述

  • 产品名称Anti-SIKE1抗体
    参阅全部 SIKE1 一抗
  • 描述
    兔多克隆抗体to SIKE1
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    antigen sequence: AEPVLKAHQS HSAEIESQID RICEMGEVMR KAVQVDDDQF CKIQEKLAQL ELENKELREL LSISSESLQA RKENSMD, corresponding to C terminal amino acids 124-200 of Human SIKE1.

  • 阳性对照
    • Human rectum tissue; Human liver and tonsil lysates; RT 4 and U 251 MG cell lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab121860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

靶标

  • 功能Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
  • 组织特异性Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
  • 序列相似性Belongs to the SIKE family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ21168 antibody
    • RGD1311316 antibody
    • RP5-1000E10.4 antibody
    • SIKE antibody
    • sike1 antibody
    • SIKE1_HUMAN antibody
    • Suppressor of IKBKE 1 antibody
    • Suppressor of IKK-epsilon antibody
    see all

Anti-SIKE1 antibody 图像

  • Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells)
    Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)
  • ab121860, at 1/150 dilution, staining SIKE1 in glandular cells of paraffin-embedded Human rectum tissue by Immunohistochemistry.
  • All lanes : Anti-SIKE1 antibody (ab121860) at 1/250 dilution

    Lane 1 : RT 4 cell lysate
    Lane 2 : U 251 MG cell lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

Anti-SIKE1 antibody (ab121860)参考文献

ab121860 has not yet been referenced specifically in any publications.

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