Anti-Signal肽Peptidase抗体(ab113872)

概述

  • 产品名称Anti-Signal肽Peptidase抗体
    参阅全部 Signal Peptide Peptidase 一抗
  • 描述
    兔多克隆抗体to Signal肽Peptidase
  • 特异性ab113872 will recognise isoform 1, 3 and 4 UniProt ID Q9D8V0
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 240-289 (IKLVFPQDLL EKGLEADNFA MLGLGDIVIP GIFIALLLRF DISLKKNTHT) of Mouse Signal Peptide Peptidase (Q9D8V0 isoform 1).

  • 阳性对照
    • Mouse Spleen lysate

性能

应用

Our Abpromise guarantee covers the use of ab113872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.
  • 组织特异性Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
  • 序列相似性Belongs to the peptidase A22B family.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Cell membrane and Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • dJ324O17.1 antibody
    • H13 antibody
    • hIMP1 antibody
    • Histocompatibility (minor) 13 antibody
    • HM13 antibody
    • HM13_HUMAN antibody
    • IMP-1 antibody
    • IMP1 antibody
    • IMPAS antibody
    • IMPAS-1 antibody
    • Intramembrane protease 1 antibody
    • Intramembrane protease antibody
    • Minor histocompatibility antigen 13 antibody
    • Minor histocompatibility antigen H13 antibody
    • MSTP086 antibody
    • OTTHUMP00000030527 antibody
    • OTTHUMP00000030528 antibody
    • OTTHUMP00000030530 antibody
    • OTTHUMP00000214528 antibody
    • Presenilin-like protein 3 antibody
    • PSENL3 antibody
    • PSL3 antibody
    • Signal peptide peptidase antibody
    • Signal peptide peptidase beta antibody
    • SPP antibody
    see all

Anti-Signal Peptide Peptidase antibody 图像

  • Anti-Signal Peptide Peptidase antibody (ab113872) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 41 kDa

Anti-Signal Peptide Peptidase antibody (ab113872)参考文献

ab113872 has not yet been referenced specifically in any publications.

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