Anti-Sigma1-receptor抗体- C-terminal (ab53852)
Key features and details
- Rabbit polyclonal to Sigma1-receptor - C-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Sigma1-receptor抗体- C-terminal
参阅全部 Sigma1-receptor 一抗 -
描述
兔多克隆抗体to Sigma1-receptor - C-terminal -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat
预测可用于: Cow, Dog, Human, Mink -
免疫原
Synthetic peptide corresponding to Rat Sigma1-receptor (C terminal).
Database link: Q99720 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53852于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).
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说明 |
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WB
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). |
靶标
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功能
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. -
组织特异性
Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. -
疾病相关
Amyotrophic lateral sclerosis 16, juvenile -
序列相似性
Belongs to the ERG2 family. -
细胞定位
Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. - Information by UniProt
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数据库链接
- Entrez Gene: 538903 Cow
- Entrez Gene: 481587 Dog
- Entrez Gene: 10280 Human
- Entrez Gene: 18391 Mouse
- Entrez Gene: 29336 Rat
- Omim: 601978 Human
- SwissProt: Q58DH7 Cow
- SwissProt: Q99720 Human
see all -
别名
- Aging associated gene 8 protein antibody
- Aging-associated gene 8 protein antibody
- AL024364 antibody
see all
图片
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All lanes : Anti-Sigma1-receptor antibody - C-terminal (ab53852) at 2 µg/ml
Lane 1 : Mouse brain homogenate
Lane 2 : Rat liver homogenate
Lane 3 : Rat brain homogenate
Predicted band size: 25 kDa
Observed band size: 25 kDa
Additional bands at: 75 kDa. We are unsure as to the identity of these extra bands.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (32)
ab53852 被引用在 32 文献中.
- Shin SM et al. Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain. Gene Ther 29:1-15 (2022). PubMed: 32424233
- Song L et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res 1:142-156 (2022). PubMed: 36051854
- Szabó Í et al. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology 192:108612 (2021). PubMed: 34023338
- Carpio MA et al. BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites. Cell Rep 34:108827 (2021). PubMed: 33691099
- Qu J et al. Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment. Oxid Med Cell Longev 2021:8836818 (2021). PubMed: 33488945