Anti-Sigma1-receptor抗体(ab89655)

概述

  • 产品名称Anti-Sigma1-receptor抗体
    参阅全部 Sigma1-receptor 一抗
  • 描述
    兔多克隆抗体to Sigma1-receptor
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Sigma1-receptor (internal sequence).
    Database link: Q99720

性能

应用

Our Abpromise guarantee covers the use of ab89655 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 21573736
WB 1/200 - 1/2000. Predicted molecular weight: 25 kDa.
IHC-P 1/50 - 1/500.

靶标

  • 功能Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
  • 组织特异性Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells.
  • 疾病相关Amyotrophic lateral sclerosis 16, juvenile
  • 序列相似性Belongs to the ERG2 family.
  • 细胞定位Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aging associated gene 8 protein antibody
    • Aging-associated gene 8 protein antibody
    • AL024364 antibody
    • hSigmaR1 antibody
    • mSigmaR1 antibody
    • opioid receptor, sigma 1 antibody
    • opioid receptor, sigma 1 isoform 1 antibody
    • RP23 167I12.6 antibody
    • SGMR1_HUMAN antibody
    • SIG 1R antibody
    • SIG-1R antibody
    • Sigma 1-type opioid receptor antibody
    • Sigma non-opioid intracellular receptor 1 antibody
    • sigma1 receptor antibody
    • Sigma1-receptor antibody
    • Sigma1R antibody
    • Sigmar1 antibody
    • SR BP antibody
    • SR-BP antibody
    • SR31747 binding protein antibody
    • SR31747-binding protein antibody
    • SRBP antibody
    see all

Anti-Sigma1-receptor antibody (ab89655)参考文献

This product has been referenced in:
  • Hayashi T  et al. Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones. Histochem Cell Biol 135:627-37 (2011). WB, ICC/IF ; Chinese Hamster . Read more (PubMed: 21573736) »

See 1 Publication for this product

Product Wall

Application Western blot
Sample Human Cell lysate - whole cell (293 cells)
Gel Running Conditions Reduced Denaturing (12%)
Loading amount 200 µg
Specification 293 cells
Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

Dr. Marina Shenkman

Verified customer

提交于 Jun 02 2015

Application Western blot
Loading amount 35 µg
Gel Running Conditions Reduced Denaturing (4-20%)
Sample Mouse Tissue lysate - whole (mECK36)
Specification mECK36
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 37°C
Username

Abcam user community

Verified customer

提交于 Dec 04 2013

I regret to inform you that I am unable to release any information regarding the immunogen used.

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Thank you for your inquiry.

Unfortunately, we are not able to release the immunogen sequence for this particular antibody as it is proprietary information.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"